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Search for "chemotherapeutic agent" in Full Text gives 9 result(s) in Beilstein Journal of Organic Chemistry.
Constrained thermoresponsive polymers – new insights into fundamentals and applications
Beilstein J. Org. Chem. 2021, 17, 2123–2163, doi:10.3762/bjoc.17.138
Enhanced target cell specificity and uptake of lipid nanoparticles using RNA aptamers and peptides
Beilstein J. Org. Chem. 2021, 17, 891–907, doi:10.3762/bjoc.17.75
- –transferrin increased brain delivery by 2.8-fold compared to liposomes without transferrin in a BBB model and in vivo [15] and further when loaded with the chemotherapeutic agent doxorubicin. They observed increased delivery of this compound and subsequently a significant tumor regression in mouse xenografts
An overview of recent advances in duplex DNA recognition by small molecules
Beilstein J. Org. Chem. 2018, 14, 1051–1086, doi:10.3762/bjoc.14.93
Marine-derived myxobacteria of the suborder Nannocystineae: An underexplored source of structurally intriguing and biologically active metabolites
Beilstein J. Org. Chem. 2016, 12, 969–984, doi:10.3762/bjoc.12.96
- metastatic breast cancer treatment, demonstrating the therapeutic potential of myxobacterial secondary metabolites [29][30][31]. This drug has also been assessed as chemotherapeutic agent in pancreatic lymphoma showing promising results and tolerable toxicity [32]. Over time, different strategies have been
A versatile δ-aminolevulinic acid (ΑLA)-cyclodextrin bimodal conjugate-prodrug for PDT applications with the help of intracellular chemistry
Beilstein J. Org. Chem. 2014, 10, 2414–2420, doi:10.3762/bjoc.10.251
- transporting the chemotherapeutic agent tamoxifen intracellularly to engage its targets while simultaneously acting as a PS. In this sense we created a bimodal system with adequate water solubility (several μM) able to inflict significant chemo- and phototoxicity on cancer cells. One additional benefit of
Olefin cross metathesis based de novo synthesis of a partially protected L-amicetose and a fully protected L-cinerulose derivative
Beilstein J. Org. Chem. 2014, 10, 1023–1031, doi:10.3762/bjoc.10.102
- ., through molecular recognition of a preferred binding site [2][3][4][5], thereby ensuring the selectivity of a chemotherapeutic agent. Particularly common are side chains composed of deoxygenated sugars [6]. For example, the kigamicins are bacterial secondary metabolites isolated from Amicolatopsis sp. [7
Concise, stereodivergent and highly stereoselective synthesis of cis- and trans-2-substituted 3-hydroxypiperidines – development of a phosphite-driven cyclodehydration
Beilstein J. Org. Chem. 2014, 10, 369–383, doi:10.3762/bjoc.10.35
- the iminosugar swainsonine, a new potential chemotherapeutic agent [27][28]. Recently, analogs of halofuginone were discovered as inhibitors of tRNA synthetases [29][30][31]. The majority of the reported syntheses [2][3][4][32][33][34][35] are elaborate (far more than 10 steps), specific on one of the
Synthesis of some novel hydrazono acyclic nucleoside analogues
Beilstein J. Org. Chem. 2010, 6, No. 49, doi:10.3762/bjoc.6.49
- using phenylhydrazine. To interpret the dominant formation of (E)-hydrazone derivatives rather than (Z)-isomers, PM3 semiempirical quantum mechanic calculations were carried out which indicated that the (E)-isomers had the lower heats of formation. Keywords: acyclic nucleoside; chemotherapeutic agent
Synthesis of phosphorothioates using thiophosphate salts
Beilstein J. Org. Chem. 2006, 2, No. 4, doi:10.1186/1860-5397-2-4
- derivatives are of interest as effective pesticides. [5][6][7][8] In recent years a number of phosphorothioates have been introduced as potential chemotherapeutic agent. [9][10][11][12] Despite their wide range of pharmacological activity, industrial and synthetic applications, the synthesis of
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